ЭПИГЕНЕТИКА СЕГОДНЯ И ЗАВТРА

CC BY - Creative Commons Attribution 4.0 International

RAI : 20.500.11925/873014

Год создания: 2013
Дата публикации в реестре: 25.08.2017


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<p align="LEFT">Эпигенетика <span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">– </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">наука о наследуемых свойствах организма</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">которые не связаны с изменением собствен</span></span></span>но нуклеотидной последовательности ДНК и могут быть не прямо<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">а опосредованно закодированы в </span></span></span>геноме<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">К числу известных эпигенетических механизмов </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">(</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">сигналов</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">) </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">относятся</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">: </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">энзиматическое мети</span></span></span>лирование ДНК<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">гистоновый код </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">(</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">разные энзиматические модификации гистонов </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">– </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">ацетилирование</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span>метилирование<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">фосфорилирование</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">убиквитинирование и др</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">.) </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">и замалчивание генов малыми РНК </span></span></span>(miRNA, siRNA). <span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Обычно все эти процессы взаимосвязаны и иногда даже частично взаимозаменяемы</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span>Это<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">скорее всего</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">служит обеспечению надежности реализации соответствующей эпигенетической </span></span></span>сигнализации<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Так или иначе эти процессы связаны с изменением структурной и функциональной </span></span></span>организации хроматина.<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Метилирование ДНК у растений и животных</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">осуществляемое сайт</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">-</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">специ</span></span></span>фическими ферментами -<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">цитозиновыми ДНК</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">-</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">метилтрансферазами</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, – </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">приводит к возникновению в </span></span></span>ней остатков <span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">5-</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">метилцитозина </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">(m</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: xx-small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: xx-small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: xx-small;">5</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">C) </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">в последовательностях </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">CG, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">С</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">NG </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">и С</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">NN. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">У растений открыто </span></span></span>еще и адениновое метилирование ДНК<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Появление остатков </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">m</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: xx-small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: xx-small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: xx-small;">5</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">C </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">в ДНК существенно сказывается </span></span></span>на взаимодействии ДНК с разными<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">в том числе и регуляторными</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">белками</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Часто метилирование </span></span></span>ДНК блокирует связывание ДНК с такими белками и препятствует транскрипции генов<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">а иногда </span></span></span>оно наоборот является обязательным условием для связывания белков<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Существуют даже специаль</span></span></span>ные <span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">m</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: xx-small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: xx-small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: xx-small;">5</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">C</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">р</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">G </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">ДНК связывающие белки</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Связывание таких белков с ДНК аранжирует весь ансамбль </span></span></span>белков транскрипционного аппарата и необходимо для его активности.<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Таким образом</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">метилиро</span></span></span>вание ДНК может служить сигналом как позитивного<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">так и негативного контроля за активностью </span></span></span>генов<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Метилирование ДНК у эукариот видо</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">- </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">и тканеспецифично</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">оно контролируется гормонами</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span>изменяется с возрастом и является одним из механизмов клеточной и половой дифференцировки. Метилирование ДНК контролирует все генетические процессы <span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">(</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">репликация ДНК</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">репарация</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">реком</span></span></span>бинация<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">транскрипция и др</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">.). </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Нарушение метилирования ДНК и искажение других эпигенетических </span></span></span>сигналов приводят к преждевременному старению и таким заболеваниям<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">как рак</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">диабет</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">астма</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span>различные тяжелые психические расстройства и др<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Профиль метилирования ДНК изменяется при </span></span></span>канцерогенезе<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">служит надежным диагностическим признаком разных форм рака уже на ранних эта</span></span></span>пах канцерогенеза<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Эпигенетические параметры имеют первостепенное значение для расшифровки </span></span></span>механизмов сомаклональной изменчивости<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">характеристики и идентификации клонов и клеточных </span></span></span>культур <span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">(</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">стволовые клетки</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">) </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">и их направленной дифференцировки</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Целенаправленное изменение </span></span></span>метилирования ДНК служит эффективным биотехнологическим средством активации экспрессии генов запасных белков семян у растений и<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">например</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">наследуемого увеличения белковости зерна </span></span></span>пшениц<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Ингибитор метилирования ДНК </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">(5-</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">азацитидин</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">) </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">используется для лечения рака кожи</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Разные </span></span></span>регуляторы энзиматических модификаций гистонов уже нашли клиническое применение при лечении некоторых болезней человека и животных<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Большие надежды возлагаются сегодня на использование </span></span></span>специфических малых РНК в терапии рака и других болезней<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">это преимущественно связывают с </span></span></span>направленным ингибированием активности генов<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">отвечающих за раковую трансформацию клеток </span></span></span>и метастазирование<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Терапевтическое действие многих коротких биологически активных пептидов </span></span></span>во многом может определяться их действием на эпигенетическом уровне<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Таким образом</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">фенотип </span></span></span>на самом деле представляет собой продукт совокупной реализации генома и эпигенома<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">. </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">В этой  </span></span></span>связи вполне справедливо известное выражение Нобелевского лауреата Питера Медавара <span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">«</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Генети</span></span></span>ка предполагает<span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">а эпигенетика располагает</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">». </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">Эпигенетика является бурно развивающейся</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">очень </span></span></span>перспективной наукой <span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">XXI </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">в</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">., </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">уже основательно проросшей в передовые биотехнологии</span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;">, </span></span></span><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA"><span style="color: #231f20; font-family: TimesNewRomanPSMT; font-size: small;" lang="JA">медицину </span></span></span>и сельское хозяйство.</p><p> </p>

Язык:
rus

Тип:
Научные статьи

Банк знаний:
Научные журналы на платформе Elpub

Источник:
Вавиловский журнал генетики и селекции




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